SSRI · generic Zoloft

Sertraline.

The most prescribed antidepressant in the United States, with the broadest set of approved uses. Once a day, with food if your stomach is sensitive.

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sertraline

At a glance

Typical dose

50 mg daily

Your physician sets your dose.

Form

Tablet

Generic, from a licensed US pharmacy.

Regulatory status

FDA-approved for depression, panic disorder, social anxiety disorder, PTSD and OCD.

Used in: Low mood Anxiety

What to expect

The timeline.

Weeks 1 to 2Stomach upset is the most common early effect. Usually settles.
Weeks 4 to 8Full effect. Dose is often adjusted once along the way.
StoppingTapered slowly with your physician.

Common side effects

Nausea, loose stools, headache, sleep changes, reduced libido or delayed orgasm.

Not suitable for

Anyone taking an MAOI or pimozide. Tell your physician if you are pregnant, or have bipolar disorder or a bleeding disorder.

FDA boxed warning

Antidepressant-class medications can increase suicidal thoughts and behaviour in children, adolescents and adults under 25, particularly in the first weeks or after a dose change. Watch for any change in mood and contact your physician straight away. In crisis, call or text 988.

This is a summary, not the full prescribing information. Read the leaflet that comes with your medication. Report side effects to your physician, or to the FDA at 1-800-FDA-1088.

The evidence

Ranked among the best balance of efficacy and acceptability across 21 antidepressants (Cipriani et al., The Lancet, 2018).

Published trial results, not okay. patient outcomes.

Sertraline

$45/mo

Includes physician care, messaging, medication if prescribed, and free discreet shipping.

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