NDRI · generic Wellbutrin XL

Bupropion XL.

Works on dopamine and noradrenaline rather than serotonin. Tends to be energising, and is far less likely to cause sexual side effects or weight gain.

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bupropion

At a glance

Typical dose

150 mg each morning

Your physician sets your dose.

Form

Extended-release tablet

Generic, from a licensed US pharmacy.

Regulatory status

FDA-approved for depression and seasonal affective disorder. Use for ADHD is off-label.

Used in: Low mood Focus Quit smoking

What to expect

The timeline.

Weeks 1 to 2Taken in the morning. Can cause dry mouth or trouble sleeping early on.
Weeks 4 to 6Full effect on mood, energy and drive.
OngoingSwallow whole. Never crush or double up on a missed dose.

Common side effects

Dry mouth, insomnia, headache, jitteriness, reduced appetite.

Not suitable for

Anyone with a seizure disorder, a current or past eating disorder (anorexia or bulimia), or who is abruptly stopping alcohol or sedatives. Not with MAOIs.

FDA boxed warning

Antidepressant-class medications can increase suicidal thoughts and behaviour in children, adolescents and adults under 25, particularly in the first weeks or after a dose change. Watch for any change in mood and contact your physician straight away. In crisis, call or text 988.

This is a summary, not the full prescribing information. Read the leaflet that comes with your medication. Report side effects to your physician, or to the FDA at 1-800-FDA-1088.

The evidence

Comparable efficacy to SSRIs for depression with lower rates of sexual side effects in head-to-head trials.

Published trial results, not okay. patient outcomes.

Bupropion XL

$49/mo

Includes physician care, messaging, medication if prescribed, and free discreet shipping.

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